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Neuroscientists find possible physical traces of short-term memories

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June 2 (UPI) — The brain must store memories to learn and acquire knowledge, but where do these memories go, and what do they look like? Finally, scientists have some answers.

In the early 20th century, the German scientist Richard Semon, a memory researcher and evolutionary biologist, coined the term “engram” for the physical substrate of a memory. Scientists have been looking for them ever since.

“Where are the engrams? This was one of the questions we asked,” Peter Jonas, neuroscientist at the Institute of Science and Technology in Austria, said in a news release.

“Synaptic plasticity, the strengthening of communication between neurons, explains memory formation at the subcellular level,” Jonas said. “To find the engram, we, therefore, explored structural correlates of synaptic plasticity.”

Jonas and his colleagues precisely measured the activity of single synapses inside the hippocampus, the region of the brain responsible for learning and memory. Inside the hippocampus, pyramidal cells are linked with granule cells by synapses.

“We made simultaneous recordings of electrical signals from a small pre-synaptic terminal and its postsynaptic target neuron,” said IST postdoctoral researcher David Vandael. “This is the perfect way to examine the synapse.”

The observations showed that when a granule cell fires, it triggers a kind of plasticity called post-tetanic potentiation, which boosts the link between the granule and pyramidal cell for a few minutes.

Scientists hypothesized that plasticity arises when heightened neuronal activity primes vesicles to release neurotransmitters. Vesicles are cellular components that facilitate the uptake and release of communicative molecules.

“Instead, we found that after a granule cell is active, more vesicles containing neurotransmitter are stored at the pre-synaptic terminal,” Vandael said. “Firing patterns induce plasticity through an increase of vesicles in this active zone, which can be stored for a few minutes.”

In other words, plasticity allows for storage, not necessarily the release of neurotransmitters.

The new research showed that during learning, when granule cells are more active, vesicles flood the active zone. When activity tapers, these vesicles remain, and when activity picks back up, the vesicles are ready and in position to release neurotransmitters into the synapse.

“Short-term memory might be activity stored as vesicles that are released later,” Vandael said.

It’s possible, scientists surmise, that the activity observed by the IST research team — and detailed Tuesday in the journal Neuron — is, in fact, the elusive engram.

“By analyzing the biophysical and structural components of plasticity, David may have discovered the engram — if we believe that synaptic plasticity underlies learning,” Vandael said.

“It is fascinating to think of memories as numbers of neurotransmitter-containing quanta, and we truly believe it will be inspiring for the neuroscience research community,” Vandael said. “We hope our work will contribute to solving part of the unresolved mysteries of learning and memory.”



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Once exposed to humans, animals start to lose their fear of predators

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Sept. 22 (UPI) — New research suggests animals begin to lose their fear of predators once they start encountering humans on a regular basis.

For the study, scientists surveyed the findings of 173 peer-reviewed papers on predator avoidance behaviors and traits deployed by 102 species of domesticated, captive and urbanized mammals, birds, reptiles, fish and mollusks.

The analysis, published Tuesday in the journal PLOS Biology, showed predator avoidance traits and behaviors, including vigilance, freezing and fleeing, decreased as a result of exposure to humans.

Researchers found individual variation in anti-predator characteristics increased upon a species’ initial exposure to humans, but then gradually decreased after generations of human exposure.

“While it is well known that the fact of being protected by humans decreases anti-predator capacities in animals, we did not know how fast this occurs and to what extent this is comparable between contexts,” lead researcher Benjamin Geffroy, biologist at the University of Montpellier in France, said in a news release.

The findings suggest behavioral flexibility allows for the initial increase in the variability of anti-predator traits, but researchers suspect genetic changes solidify declines in predator avoidance as subsequent generations adjust to the presence of humans.

In the studies analyzed by Geffroy and his colleagues, domesticated animals lose their anti-predator traits much more quickly than urbanized animals, which can cause problems when domesticated or urbanized species are released back into the wild.

“We also integrated physiological traits in the study but they were much less numerous that behavioral traits,” Geffroy said. “We believe they should be systematically investigated to draw a global pattern of what is happening at the individual level.

“We need more data to understand whether this occurs also with the mere presence of tourists,” Geffroy said.



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Search and rescue dogs fared well after work at 9/11 sites, study says

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Search and rescue dogs used during the 9/11 attacks lived as long as dogs not at the World Trade Center in New York City and the Pentagon, a new study finds.

“I was at Ground Zero and I would hear people make comments like, ‘Did you hear that half of the dogs that responded to the bombing in Oklahoma City died of X, Y, or Z?’ Or they’d say dogs responding to 9/11 had died,” said Dr. Cynthia Otto, director of the University of Pennsylvania’s Working Dog Center, in Philadelphia. “It was really disconcerting.”

Otto and her School of Veterinary Medicine colleagues’ findings are reassuring.

Dogs that participated in search-and-rescue efforts after 9/11 lived as long as search-and-rescue dogs not at the scene — a median of about 12.8 years, meaning half died sooner, half did not. They also outlived the life spans of their breed. There was no difference in the dogs’ cause of death.

“Honestly, this was not what we expected it’s surprising and wonderful,” said Otto, a veterinarian.

The researchers expected to see respiratory problems in the exposed dogs, but they did not. The most common cause of death was age-related conditions, such as arthritis and cancer.

For the study, Otto collected data on 95 dogs that had worked at the World Trade Center, the nearby Fresh Kills Landfill in Staten Island, N.Y., or Pentagon disaster sites in Washington, D.C. They compared these dogs with 55 search-and-rescue dogs that were not deployed on 9/11.

“We anticipated that the dogs would be the ‘canary in the coal mine’ for the human first responders since dogs age faster than humans and didn’t have any of the protective equipment during the response,” Otto said in a university news release. “But we didn’t see a lot that was concerning.”

Generally, these dogs are stronger and healthier than pets, which might partly explain why the dogs fared well, she said.

The findings were published Sept. 21 in the Journal of the American Veterinary Medical Association.

More information

For more on responder health after 9/11, visit the New York State Department of Health.

Copyright 2020 HealthDay. All rights reserved.



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Experience, charisma will steer NASA’s choice for first woman on moon

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ORLANDO, Fla., Sept. 23 (UPI) — Experience, charisma — and previous exposure to radiation in space — will guide NASA’s history-making decision to choose the first woman who walks on the moon, according to those familiar with space agency operations.

NASA Administrator Jim Bridenstine has said the woman selected will be an experienced astronaut who has flown on space missions. Ten current astronauts meet that criteria, and more could soon.

In addition to expertise, NASA will look at the ability to perform well on high-profile missions and to connect with the public, space exploration observers said.

Some of the most experienced astronauts could be ruled out if they have too much radiation exposure, according to space medicine experts.

Among the potential moon mission candidates, astronauts Christina Koch, 41, and Jessica Meir, 43, raised their profiles earlier this year by carrying out the first-ever all-female spacewalk while stationed on the International Space Station. Koch also set a record for living in space longer than any other woman at 328 days.

Koch and Meir’s stature most likely improved after completing their tandem spacewalk, said Nancy Vermeulen, an astrophysicist, pilot and founder of the Belgium-based Space Training Academy.

High pressure

They demonstrated that the two women could work together in a high-pressure situation under the media spotlight, Vermeulen said.

“NASA monitors the synergy among astronauts on a team, how people cooperate together,” she said.

But those achievements will pale when compared to walking on the moon, said retired astronaut Kathryn Sullivan, the first American woman to walk in space in 1984.

NASA is keenly aware that a moon mission “will catapult this woman, whoever she is [and] make her an icon and role model in a different way than most astronauts,” Sullivan said.

Despite creating that fame, NASA’s first priority will be “to make sure this mission will succeed and the crew has the right capabilities and chemistry,” she said.

Of NASA’s 48 active astronauts, 16 are women. Bridenstine and Vice President Mike Pence have committed to sending one of them on the first moon landing in 2024. Four astronauts will make the journey, and two will land, including the woman.

At a 2019 event, Bridenstine went further, saying the 2024 mission could have more than one woman.

As for the actual selection, NASA first will identify an as-yet unknown number of Artemis astronauts to train others and help establish requirements for flights to and around the moon, Bridenstine said in August.

Elite group

“This elite group will include some of the men and women who will fly on early Artemis missions, and we will add more to the team in the future,” Bridenstine said via email.

In terms of experience, and among those who could lead the way, three female astronauts have flown on more than one mission.

Sunita Williams, 54, spent 322 days in space over the course of two missions. She is scheduled for her third mission in early 2021 aboard Boeing’s Starliner space capsule, should it pass its final uncrewed flight test planned for December.

In 2006, Williams served as a flight engineer on a space shuttle mission to the International Space Station. In 2012, she was launched aboard a Russian Soyuz capsule to the space station.

Williams carried out seven spacewalks, and she and retired astronaut Peggy Whitson broke records for most spacewalks by a woman. Whitson currently holds the mark with 10.

Tracy Caldwell Dyson, 51, flew on a space shuttle mission in August 2007, which added equipment and structural parts to the International Space Station. In 2010, she was launched aboard a Russian Soyuz capsule and spent 174 days living and working aboard the space station as a flight engineer.

Stephanie Wilson, 53, has flown three space shuttle missions — all of which were about two weeks long — in 2006, 2007 and 2010. All three missions delivered equipment and supplies to the space station. Wilson operated the station’s robotic arm and served as flight engineer, assisting the commander and pilot.

Oldest person ever

If NASA choses one of these women for a lunar landing, she would be the oldest person ever walk on the moon.

Apollo moonwalkers’ ages ranged from the youngest, Charlie Duke at 36, to Alan Shepherd at 47. Spaceflight experts said age no longer is the barrier it once was, but physical fitness and agility will be important to endure the mission and move about in cumbersome spacesuits.

In the next year, at least three more women are scheduled to fly on their second space mission — Megan McArthur, 49, Kathleen Rubins, 41, and Shannon Walker, 55.

And three astronauts have been to space once — Koch, Meir and Anne McClain, 41.

Two women astronauts, Jeannette Epps, 49, and Nicole Mann, 43, are scheduled for their first trip into space within the next 12 months.

Five women have yet to go into space and have no scheduled missions — Zena Cardman and Kayla Barron, both 32; Jasmin Moghbeli, 37; Loral O’Hara, 37, and Jessica Watkins, 32.

High-profile mission

NASA chooses astronauts carefully for all missions, and especially so for historical milestones, retired astronaut Sullivan said.

That includes Neil Armstrong, Buzz Aldrin and Michael Collins on Apollo 11 and John Young and Robert Crippen on the first space shuttle launch. Sending the first American woman, Sally Ride, into space also was a high-profile decision.

Armstrong was chosen for Apollo 11 because he was a test pilot and an engineer. NASA officials selected him over crewmate Buzz Aldrin to step on the moon first because they thought he didn’t have as big an ego, according to a 2001 book by the late Chris Kraft, NASA’s first flight director.

NASA picked Young as the first space shuttle mission commander in 1981 because he was a seasoned space veteran with four missions and a walk on the moon.

Sullivan said that neither she nor Ride knew why they were chosen for their historic missions.

The role that astronauts assume on such missions as a standard-bearer for NASA and the nation weighs heavily on the choice. But subtle psychological issues come into play, as well, Sullivan said.

Need to be photogenic

“I wouldn’t be shocked if the choice of a woman for the moon mission is sort of slanted toward someone photogenic,” Sullivan said. “It’s virtually never in play with men, but it’s been a subconscious factor at NASA for women.

“There are archetypes that resonate more with society, and I think that’s going to be a factor.”

She wrote about NASA’s view of women in her book, Handprints on Hubble, which also describes the triumphs and frustrations of her career and how she came to deploy the storied telescope in orbit.

While the space agency may value charisma, technical requirements for the first such deep-space mission in decades will be paramount, said Brian C. Odom, the acting NASA chief historian.

“NASA will take everything they’ve learned over the decades and apply those lessons to this decision” on crew members, Odom said.

“Historically, crew selection depends on the mission and what astronauts are expected to do, so the first mission of its kind often has had pilots and engineers prove the spacecraft capability,” Odom said.

Connect with public

Even so, NASA may favor astronauts who have shown an ability to connect with the public such a historic mission, he said.

“Historically, the expectation is that they would be very adept at speaking to the public,” Odom said. “NASA aims to inspire people to get involved and follow in the footsteps of astronauts.”

While experience is crucial, a limiting factor could be radiation to which astronauts have been exposed.

“I doubt age will matter as much as previous radiation exposure, which NASA does consider when choosing astronauts for long-term missions,” said Virginia Wotring, a scientist with the International Space University in France. Her career has focused on health impacts of extended duration space flights.

NASA will disqualify astronauts for having an elevated cancer risk, based on measurements kept by their personal radiation counters, or dosimeters. At the International Space Station, astronauts receive about 10 times the amount of radiation they do on Earth.

Because deep-space missions have a higher risk of radiation exposure, the most likely candidates are those with one successful mission, Wotring said. They would be Koch, Meir, McClain and possibly Mann and Epps after they return from space.

Most radiation

At the same time, Koch’s record duration in space for a woman means she also has been exposed to more radiation than the other women. But because older astronauts are thought to have less time to develop cancer, they may not be disqualified based more radiation absorbed, Wotring said.

Mission requirements also may mandate that someone with geology expertise be on the first Artemis landing. That’s because NASA confirmed this week it will investigate water ice on the first landing. Astronaut Watkins is a geologist.

The timing remains uncertain for naming the crew to make this first return to the moon flight. NASA doesn’t have a timeline for specific flight assignment announcements, the space agency has said.

But NASA will approach that announcement with caution, said Amy Foster, associate professor at the University of Central Florida, who specializes in space history.

While women are a minority among the 48-member astronaut corps, the space agency also could make a statement by selecting a women who represents another minority, Foster said.

Three of the eligible women astronauts are African American — Epps, Watkins and Wilson. Moghbeli is Iranian-American, while McClain is the only known gay or lesbian astronaut.

However, it’s quite likely NASA will pick a woman astronaut who otherwise is not a minority, Foster said. “Right now, I think checking the one box, in terms of historical minorities [among astronauts], is as risky as NASA will be,” she said.

New generation

In making its decision, NASA also will seek to appeal to a new generation of Americans who weren’t born when man first walked on the moon.

Sending the first woman there will be almost as important as repeating a landing for the first time since 1972, said astronaut Serena Aunon-Chancellor, who has retired from spaceflight, but still helps to train other astronauts.

“My hope is that young women from all over the world will watch these tremendous events unfold and, without hesitation, begin to forge their own path in space exploration,” Aunon-Chancellor said in a statement to UPI.

The first woman moonwalker will be an icon for girls, women and society for many years to come, the International Space University’s Wotring said.

“I find myself in a strange position when I’m talking to young people who tell me that as a woman scientist, I am inspirational to them, and I’m just working in a lab here on campus,” she said.

“So I think it’s going to be incredibly powerful to see a woman walking on the moon — and change the equation forever.”

NASA’s 16 women astronauts — at least one likely to walk on moon

Tracy Caldwell Dyson pauses for a portrait in her spacesuit before going underwater in the Neutral Buoyancy Lab at NASA’s Johnson Space Center in Houston on July 8, 2019. Photo by Bill Ingalls/UPI



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