Connect with us

Health

Gene-targeted asthma meds for kids show promise in trial

Published

on

Asthma treatments tailored to the genes of kids and teens could help improve control of their symptoms, new research suggests.

The study included 241 adolescents, aged 12 to 18, who were randomly selected to receive either traditional asthma treatment or “personalized medicine” — treatment based on their individual genetics.

During a year of follow-up, those in the personalized medicine group who had a genetic difference in a receptor gene targeted by asthma treatments reported a better quality-of-life score. The score was based on their symptoms, whether their normal activities were limited by their asthma, and how their asthma made them feel.

While more research is needed, the findings suggest personalized treatment could better control asthma in young people, according to the researchers.

The study — the first of its kind in children and teens — was presented recently at a virtual meeting of the European Respiratory Society. Research presented at meetings should be considered preliminary until published in a peer-reviewed journal.

“These results are very promising because they show, for the first time, that it could be beneficial to test for certain genetic differences in children with asthma and select medication according to those differences,” said study leader Somnath Mukhopadhyay. He is chair of pediatrics at Royal Alexandra Children’s Hospital, Brighton and Sussex Medical School in East Sussex, U.K.

The approach is an important goal for respiratory research, said Christopher Brightling, chair of the European Respiratory Society Science Council, who reviewed the findings.

“In this study, researchers used genetic information that we know is linked to how well patients respond to some inhaler treatments. They found that making use of this genetic information improved the outcome for children with asthma,” Brightling said in a European Respiratory Society news release.

Asthma is a common condition in children that causes coughing, wheezing and difficulty breathing. About 5.5 million children under 18 in the United States have asthma, according to the U.S. Centers for Disease Control and Prevention.

More information

The American Lung Association has more on asthma and children.

Copyright 2020 HealthDay. All rights reserved.



Source link

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Health

Asthma, food sensitivity linked to irritable bowel syndrome in study

Published

on

Teens who had asthma and food hypersensitivity when they were younger are at increased risk of irritable bowel syndrome, researchers report.

For the study, the investigators examined the health of 2,770 children from birth to age 16. Kids with IBS at age 16 were more likely to have had asthma at age 12, about 11% versus 7%.

In addition, the researchers found that 16-year-olds with IBS were more likely to have had food hypersensitivity at age 12, 41% versus 29%.

Asthma, food hypersensitivity and eczema — a condition that makes your skin red and itchy — were all associated with an increased risk of concurrent IBS at age 16, the findings showed.

“The associations found in this large study suggest there’s a shared pathophysiology between common allergy-related diseases and adolescent irritable bowel syndrome,” said study leader Jessica Sjölund, of the Institute of Medicine at the University of Gothenburg, in Sweden.

Sjölund noted that previous studies on allergy-related diseases and IBS have been contradictory.

These new findings could lead to development of new treatments for adolescent IBS, targeting processes of low-grade inflammation seen in the allergy-related diseases, she said.

The study findings were scheduled for presentation Monday at a United European Gastroenterology virtual meeting. Research presented at meetings should be considered preliminary until published in a peer-reviewed journal.

IBS affects more than one in 10 people and is the most common functional gastrointestinal disorder, the study authors noted in a meeting news release. It can cause abdominal cramps, bloating, diarrhea and constipation, and can be extremely disabling for patients.

Hans Törnblom is a leading IBS expert in Europe who was involved in the research. He said, “Even though functional gastrointestinal disorders are common, many patients are, unfortunately, negatively stigmatized and labeled. The fact that many IBS sufferers do not seek medical advice should be of great concern.”

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more on IBS.

Copyright 2020 HealthDay. All rights reserved.



Source link

Continue Reading

Health

Cancer takes heavy toll on women’s work, finances, study shows

Published

on

Young women with cancer are at a high risk for employment and financial consequences, a new study finds.

“Our study addresses the burden of employment disruption and financial hardship among young women with cancer — a group who may be at particular risk for poor financial outcomes after cancer given their age and gender,” said researcher Clare Meernik, a fellow at the University of North Carolina at Chapel Hill’s Lineberger Comprehensive Cancer Center.

She and her colleagues surveyed more than 1,300 women in North Carolina and California a median of seven years after diagnosis. Their cancer was diagnosed when they were 15 to 39 years of age and working.

Following their diagnosis, 32% of the women had to stop working or cut back on their hours. Twenty-seven percent said they had to borrow money, go into debt or file for bankruptcy because of cancer treatment.

Women with disrupted employment were more likely — by 17 percentage points — to have these problems than women who were able to keep working.

Half of the women said they were stressed about their big medical bills, and women with disrupted employment were more likely to suffer psychological distress by 8 percentage points than women who were able to keep working.

The findings were published online Oct. 12 in the journal Cancer.

“Our findings highlight the need for effective interventions to promote job maintenance and transition back to the workforce after cancer treatment, as well as increased workplace accommodations and benefits, to improve cancer outcomes for young women,” Meernik said in a journal news release.

More information

To learn more about work and financial effects of cancer, visit the American Cancer Society.

Copyright 2020 HealthDay. All rights reserved.



Source link

Continue Reading

Health

Study: Less restrictive reproductive rights reduce birth complications risk by 7%

Published

on

Oct. 13 (UPI) — Women living in states with less restrictive reproductive rights policies are 7% less likely have low birth weight babies than those living in states with more stringent laws, according to an analysis published Tuesday by the American Journal of Preventive Medicine.

The risk was 8% lower for Black women living in less-restrictive states, the data showed.

“Our study provides evidence that reproductive rights policies play a critical role in advancing maternal and child health equity,” study co-author May Sudhinaraset, of the UCLA Fielding School of Public Health, said in a statement.

Since the Supreme Court‘s decision in Roe v. Wade in 1973, which effectively legalized abortion, states have had “substantial discretion” in creating policies governing whether Medicaid covers the costs of contraception or reproductive health care.

Some states have taken steps that effectively limit access to abortion services and other reproductive care, Sudhinaraset and her colleagues said.

Black women are more likely to die in pregnancy and childbirth than any other race group, experience more maternal health complications than White women and generally have lower quality maternity care, they said.

In addition, women of color are more likely to experience adverse birth outcomes.

Compared to infants of normal weight, low-birth-weight babies face many potential health complications, including infections early in life and long-term problems, such as delayed motor and social development or learning disabilities.

Sudhinaraset and her colleagues analyzed birth record data for the nearly 4 million births that occurred in the 50 states and Washington, D.C., in 2016, comparing reproductive rights policies and adverse birth outcomes in each state.

They also evaluated if the associations were different for women of color and immigrants.

The findings indicate that expanding reproductive rights may reduce the risk of low-birth weight, particularly for U.S.-born Black women, the researchers said.

“Important policy levers can and should be implemented to improve women’s reproductive health overall, including increasing abortion access and mandatory sex education in schools,” Sudhinaraset said.



Source link

Continue Reading

Trending